Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1
Identifieur interne : 002B66 ( Main/Exploration ); précédent : 002B65; suivant : 002B67Malaria Parasite-Infected Erythrocytes Secrete PfCK1, the Plasmodium Homologue of the Pleiotropic Protein Kinase Casein Kinase 1
Auteurs : Dominique Dorin-Semblat [France] ; Claudia Demarta-Gatsi [France] ; Romain Hamelin [Suisse] ; Florence Armand [Suisse] ; Teresa Gil Carvalho ; Marc Moniatte [Suisse] ; Christian DoerigSource :
- PLoS ONE [ 1932-6203 ] ; 2015.
Descripteurs français
- KwdFr :
- Casein kinase I (génétique), Casein kinase I (métabolisme), Clonage moléculaire, Humains, Immunoprécipitation, Paludisme (enzymologie), Paludisme (parasitologie), Phosphorylation, Plasmodium falciparum (enzymologie), Protéines de protozoaire (génétique), Protéines de protozoaire (métabolisme), Technique d'immunofluorescence, Technique de Southern, Technique de Western, Érythrocytes (enzymologie), Érythrocytes (parasitologie).
- MESH :
- enzymologie : Paludisme, Plasmodium falciparum, Érythrocytes.
- génétique : Casein kinase I, Protéines de protozoaire.
- métabolisme : Casein kinase I, Protéines de protozoaire.
- parasitologie : Paludisme, Érythrocytes.
- Clonage moléculaire, Humains, Immunoprécipitation, Phosphorylation, Technique d'immunofluorescence, Technique de Southern, Technique de Western.
English descriptors
- KwdEn :
- Blotting, Southern, Blotting, Western, Casein Kinase I (genetics), Casein Kinase I (metabolism), Cloning, Molecular, Erythrocytes (enzymology), Erythrocytes (parasitology), Fluorescent Antibody Technique, Humans, Immunoprecipitation, Malaria (enzymology), Malaria (parasitology), Phosphorylation, Plasmodium falciparum (enzymology), Protozoan Proteins (genetics), Protozoan Proteins (metabolism).
- MESH :
- chemical , genetics : Casein Kinase I, Protozoan Proteins.
- chemical , metabolism : Casein Kinase I, Protozoan Proteins.
- enzymology : Erythrocytes, Malaria, Plasmodium falciparum.
- parasitology : Erythrocytes, Malaria.
- Blotting, Southern, Blotting, Western, Cloning, Molecular, Fluorescent Antibody Technique, Humans, Immunoprecipitation, Phosphorylation.
Abstract
Casein kinase 1 (CK1) is a pleiotropic protein kinase implicated in several fundamental processes of eukaryotic cell biology.
Url:
DOI: 10.1371/journal.pone.0139591
PubMed: 26629826
PubMed Central: 4668060
Affiliations:
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sortKey="Dorin Semblat, Dominique" sort="Dorin Semblat, Dominique" uniqKey="Dorin Semblat D" first="Dominique" last="Dorin-Semblat">Dominique Dorin-Semblat</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>UMR S1134, Institut National de Transfusion Sanguine, 6 Rue Alexandre Cabanel, 75015 Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR S1134, Institut National de Transfusion Sanguine, 6 Rue Alexandre Cabanel, 75015 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Demarta Gatsi, Claudia" sort="Demarta Gatsi, Claudia" uniqKey="Demarta Gatsi C" first="Claudia" last="Demarta-Gatsi">Claudia Demarta-Gatsi</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Institut Pasteur, Unité de Biologie des Interactions Hôte-Parasites, 25–28 rue du Dr Roux, Paris F-75015, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité de Biologie des Interactions Hôte-Parasites, 25–28 rue du Dr Roux, Paris F-75015</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Hamelin, Romain" sort="Hamelin, Romain" uniqKey="Hamelin R" first="Romain" last="Hamelin">Romain Hamelin</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Proteomics Core Facility, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Proteomics Core Facility, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne</wicri:regionArea><wicri:noRegion>CH-1015 Lausanne</wicri:noRegion></affiliation></author><author><name sortKey="Armand, Florence" sort="Armand, Florence" uniqKey="Armand F" first="Florence" last="Armand">Florence Armand</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Proteomics Core Facility, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Proteomics Core Facility, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne</wicri:regionArea><wicri:noRegion>CH-1015 Lausanne</wicri:noRegion></affiliation></author><author><name sortKey="Carvalho, Teresa Gil" sort="Carvalho, Teresa Gil" uniqKey="Carvalho T" first="Teresa Gil" last="Carvalho">Teresa Gil Carvalho</name><affiliation><nlm:aff id="aff004"><addr-line>Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria, Australia, 3800</addr-line></nlm:aff><wicri:noCountry code="subfield">3800</wicri:noCountry></affiliation></author><author><name sortKey="Moniatte, Marc" sort="Moniatte, Marc" uniqKey="Moniatte M" first="Marc" last="Moniatte">Marc Moniatte</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Proteomics Core Facility, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Proteomics Core Facility, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne</wicri:regionArea><wicri:noRegion>CH-1015 Lausanne</wicri:noRegion></affiliation></author><author><name sortKey="Doerig, Christian" sort="Doerig, Christian" uniqKey="Doerig C" first="Christian" last="Doerig">Christian Doerig</name><affiliation><nlm:aff id="aff004"><addr-line>Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria, Australia, 3800</addr-line></nlm:aff><wicri:noCountry code="subfield">3800</wicri:noCountry></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blotting, Southern</term><term>Blotting, Western</term><term>Casein Kinase I (genetics)</term><term>Casein Kinase I (metabolism)</term><term>Cloning, Molecular</term><term>Erythrocytes (enzymology)</term><term>Erythrocytes (parasitology)</term><term>Fluorescent Antibody Technique</term><term>Humans</term><term>Immunoprecipitation</term><term>Malaria (enzymology)</term><term>Malaria (parasitology)</term><term>Phosphorylation</term><term>Plasmodium falciparum (enzymology)</term><term>Protozoan Proteins (genetics)</term><term>Protozoan Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Casein kinase I (génétique)</term><term>Casein kinase I (métabolisme)</term><term>Clonage moléculaire</term><term>Humains</term><term>Immunoprécipitation</term><term>Paludisme (enzymologie)</term><term>Paludisme (parasitologie)</term><term>Phosphorylation</term><term>Plasmodium falciparum (enzymologie)</term><term>Protéines de protozoaire (génétique)</term><term>Protéines de protozoaire (métabolisme)</term><term>Technique d'immunofluorescence</term><term>Technique de Southern</term><term>Technique de Western</term><term>Érythrocytes (enzymologie)</term><term>Érythrocytes (parasitologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Casein Kinase I</term><term>Protozoan Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Casein Kinase I</term><term>Protozoan Proteins</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Paludisme</term><term>Plasmodium falciparum</term><term>Érythrocytes</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Erythrocytes</term><term>Malaria</term><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Casein kinase I</term><term>Protéines de protozoaire</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Casein kinase I</term><term>Protéines de protozoaire</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Paludisme</term><term>Érythrocytes</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Erythrocytes</term><term>Malaria</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Blotting, Southern</term><term>Blotting, Western</term><term>Cloning, Molecular</term><term>Fluorescent Antibody Technique</term><term>Humans</term><term>Immunoprecipitation</term><term>Phosphorylation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Clonage moléculaire</term><term>Humains</term><term>Immunoprécipitation</term><term>Phosphorylation</term><term>Technique d'immunofluorescence</term><term>Technique de Southern</term><term>Technique de Western</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Casein kinase 1 (CK1) is a pleiotropic protein kinase implicated in several fundamental processes of eukaryotic cell biology. <italic>Plasmodium falciparum</italic> encodes a single CK1 isoform, PfCK1, that is expressed at all stages of the parasite’s life cycle. We have previously shown that the <italic>pfck1</italic> gene cannot be disrupted, but that the locus can be modified if no loss-of-function is incurred, suggesting an important role for this kinase in intra-erythrocytic asexual proliferation. Here, we report on the use of parasite lines expressing GFP- or His-tagged PfCK1 from the endogenous locus to investigate (i) the dynamics of PfCK1 localisation during the asexual cycle in red blood cells, and (ii) potential interactors of PfCK1, so as to gain insight into the involvement of the enzyme in specific cellular processes. Immunofluorescence analysis reveals a dynamic localisation of PfCK1, with evidence for a pool of the enzyme being directed to the membrane of the host erythrocyte in the early stages of infection, followed by a predominantly intra-parasite localisation in trophozoites and schizonts and association with micronemes in merozoites. Furthermore, we present strong evidence that a pool of enzymatically active PfCK1 is secreted into the culture supernatant, demonstrating that PfCK1 is an ectokinase. Our interactome experiments and ensuing kinase assays using recombinant PfCK1 to phosphorylate putative interactors <italic>in vitro</italic> suggest an involvement of PfCK1 in many cellular processes such as mRNA splicing, protein trafficking, ribosomal, and host cell invasion.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dondorp, Am" uniqKey="Dondorp A">AM Dondorp</name></author><author><name sortKey="Yeung, S" uniqKey="Yeung S">S Yeung</name></author><author><name sortKey="White, L" uniqKey="White L">L White</name></author><author><name sortKey="Nguon, C" uniqKey="Nguon C">C Nguon</name></author><author><name sortKey="Day, Np" uniqKey="Day N">NP Day</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ward, P" uniqKey="Ward P">P Ward</name></author><author><name sortKey="Equinet, L" uniqKey="Equinet L">L Equinet</name></author><author><name sortKey="Packer, J" uniqKey="Packer J">J 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last="Carvalho">Teresa Gil Carvalho</name><name sortKey="Doerig, Christian" sort="Doerig, Christian" uniqKey="Doerig C" first="Christian" last="Doerig">Christian Doerig</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Dorin Semblat, Dominique" sort="Dorin Semblat, Dominique" uniqKey="Dorin Semblat D" first="Dominique" last="Dorin-Semblat">Dominique Dorin-Semblat</name></region><name sortKey="Demarta Gatsi, Claudia" sort="Demarta Gatsi, Claudia" uniqKey="Demarta Gatsi C" first="Claudia" last="Demarta-Gatsi">Claudia Demarta-Gatsi</name></country><country name="Suisse"><noRegion><name sortKey="Hamelin, Romain" sort="Hamelin, Romain" uniqKey="Hamelin R" first="Romain" last="Hamelin">Romain Hamelin</name></noRegion><name sortKey="Armand, Florence" sort="Armand, Florence" uniqKey="Armand F" first="Florence" last="Armand">Florence Armand</name><name sortKey="Moniatte, Marc" sort="Moniatte, Marc" uniqKey="Moniatte M" first="Marc" last="Moniatte">Marc 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